Will this hold a man weighing 450 lbs.
If you're talking about the Therapedic Medi-Coil Permatuft, you bet it will. It was designed for that purpose. Understand, though, a two sided mattress requires flipping. The frequency varies with the weight.
At 450 pounds, plan on doing that every month. Alternate your flipping...side to side, then head to foot...for the most even wear.
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